University of Kentucky


Original Research (selected publications)

Jarrett SG, Carter, KM, Shelton, BJ and D'Orazio JA. The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage. Scientifc Reports. 2017.

Wolf Horrell EM, Jarrett SG, Carter KM, D'Orazio JA. Divergence of cAMP signalling pathways mediating augmented nucleotide excision repair and pigment induction in melanocytes. Experimental Dermatology. 2017.

Jarrett SG, Wolf Horrell EM, D'Orazio JA. AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair. Nucleic Acids Research. 2016.

Jarrett SG, Wolf Horrell EM, Boulanger MC, D'Orazio JA. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes. The Journal of Investigative Dermatology. 2015.

Jarrett SG, Wolf Horrell EM, Christian PA, Vanover JC, Boulanger MC, Zou Y, D'Orazio JA. PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. Molecular Cell. 2014.

Wolf Horrell E, D'Orazio J. UV-independent induction of beta defensin 3 in neonatal human skin explants. F1000Research. 2014.

Amaro-Ortiz A, Vanover JC, Scott TL, D'Orazio JA. Pharmacologic induction of epidermal melanin and protection against sunburn in a humanized mouse model. Journal of Visualized Experiments (JoVE). 2013.

Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012.

Scott TL, Christian PA, Kesler MV, Donohue KM, Shelton B, Wakamatsu K, Ito S, D'Orazio J. Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation. Experimental Dermatology. 2012.

Vanover JC, Spry ML, Hamilton L, Wakamatsu K, Ito S, D'Orazio JA. Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice. Pigment Cell and Melanoma Research. 2009.

Spry ML, Vanover JC, Scott T, Abona-Ama O, Wakamatsu K, Ito S, D'Orazio JA. Prolonged treatment of fair-skinned mice with topical forskolin causes persistent tanning and UV protection. Pigment Cell and Melanoma Research. 2009.

Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 2007.

D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 2006.

Reviews (selected)

Jarrett SG, Carter KM, D'Orazio JA. Paracrine regulation of melanocyte genomic stability: a focus on nucleotide excision repair. Pigment Cell and Melanoma Research. 2017.

Jarrett SG, D'Orazio JA. Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis. Photochemistry and Photobiology. 2017.

Wolf Horrell EM, Boulanger MC and D’Orazio JA (2016) Melanocortin 1 Receptor: Structure, Function, and Regulation. Front. Genet. 7:95. doi: 10.3389/fgene.2016.00095.

Amaro-Ortiz A, Yan B, D'Orazio JA. Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation. Molecules. 2014.

Book Chapters (selected)

Wolf Horrell, E.M. and J.A. D'Orazio. "Melanocortin 1 receptor (MC1R) as a global regulator of cutaneous UV responses: molecular interactions and opportunities for melanoma prevention", included in "'Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities" Springer Science Books, 2016.

Wolf Horrell, EM, K Wilson and JA D’Orazio, Melanoma — Epidemiology, Risk Factors, and the Role of Adaptive Pigmentation, in “Melanoma – Current Clinical Management and Future Therapeutics”, InTech, 2015.